Enterprise Evidence Report · NR-REPORT-V2.0

United States
Neuroscience Intelligence

United States neuroscience evidence report: current clinical, research, institution and source-linked intelligence.

Evidence rank #1 of 50 · Data maturity A · Research score 66.2 · Data confidence 100.0 / 100 · Snapshot 2026-10-29 06:18 UTC.

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3,172Curated trials
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598Recruiting trials
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6,384Publications
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1,985Institutions

Executive interpretation

United States ranks #1 in the current NeuroRisk evidence-ranked market layer. This ranking summarizes indexed clinical, publication and institution evidence; it is not a probability of commercial success and not an investment recommendation.

Methodology status

Methodology NR-REPORT-V2.0. Clinical metrics and NCT evidence use only records classified as in_scope or related; out_of_scope records remain preserved outside these analytical counts. No synthetic ML confidence is presented as scientific probability. Counts and source links below are tied to the generation snapshot.

Methodology →

Leading sponsors

Massachusetts General Hospital9117 recruiting
Stanford University4515 recruiting
University of California, Los Angeles4310 recruiting
Yale University4311 recruiting
Johns Hopkins University399 recruiting
Merck Sharp & Dohme LLC3816 recruiting
University of Michigan379 recruiting
Duke University375 recruiting
Eli Lilly and Company377 recruiting
National Institute of Neurological Disorders and Stroke (NINDS)322 recruiting

Disease activity

Alzheimers462trials
Parkinsons395trials
Autism362trials
Epilepsy312trials
Depression295trials
Adhd262trials
Other Neurology131trials
Pain Neuropathy107trials
Stroke96trials
Other Psychiatry86trials

Research institutions

Sutter HealthOpenAlexlinked institution
Amyloidosis FoundationOpenAlexlinked institution
Pali Momi Medical CenterOpenAlexlinked institution
Forest Laboratories (United States)OpenAlexlinked institution
Boise State UniversityOpenAlexlinked institution
Lawrence Livermore National LaboratoryOpenAlexlinked institution
Fielding Graduate UniversityOpenAlexlinked institution

Clinical evidence trail

NCT07824206Lumateperone Added to Antidepressant Therapy in Adults With Major Depressive Disorder Experiencing Emotional BluntingNOT_YET_RECRUITING
NCT07812987Rapid Entrainment and Signal-guided Neuromodulation for Behavioral HealthACTIVE_NOT_RECRUITING
NCT07805382Dynamic Relationships Between Estrogen Fluctuations, Sleep, and Psychiatric Complexity Among Adolescent Females With ADHDNOT_YET_RECRUITING
NCT07804615A Study to Evaluate the Efficacy, PK, Safety, and Tolerability of VIM0423 in Adults With Parkinson's Disease Tremor Insufficiently Responsive to Dopaminergic TherapyRECRUITING
NCT07798297Transitional Intervention for Hyperacusis in AutismRECRUITING
NCT07796308Terazosin And Metabolic Engagement in Alzheimer's DiseaseNOT_YET_RECRUITING
NCT07793461Gastrointestinal Dopamine Decarboxylase and Levodopa PharmacokineticsNOT_YET_RECRUITING
NCT07793045Binaural Beats Stimulation for Adults With Attention-Deficit/Hyperactivity DisorderRECRUITING
NCT07779785VICA: A Virtual Care Assistant for Dementia CaregiversNOT_YET_RECRUITING
NCT07775872Prospective Natural History Study of POLG DiseaseRECRUITING
NCT07770152Semaglutide in Youth With Autism Spectrum DisorderNOT_YET_RECRUITING
NCT07764822Eye Tracking and Autism in Former Preterm InfantsNOT_YET_RECRUITING

Research evidence trail

PUBMEDThe ups and downs of human UNC93B1: Autoimmune and viral conditions.2027-01-04
PUBMEDBehavioral recovery and motor reinnervation outcomes after peripheral nerve transection with microsuture or Nerve Tape repair.2027-01-01
PUBMEDOlder adult APOE4 mice exhibit modest immunometabolic adaptation following microglial APOE2 replacement.2027-01-01
PUBMEDRegional distribution of mineralized blood vessels in Alzheimer disease and clinicopathological associations: A multicenter autopsy study.2027-01-01
PUBMEDTherapeutic hypothermia does not prevent dysmaturity of medial ganglionic eminence-derived interneurons in the dorsal hippocampus after neonatal hypoxia-ischemia.2027-01-01
PUBMEDStriatal 6-hydroxydopamine lesion in rats induces dysregulation of the gut barrier.2027-01-01
PUBMEDDevelopmental myelination deficits and impaired fine motor function in a mouse model of pediatric obstructive sleep apnea.2027-01-01
PUBMEDStructural brain indicators of cognitive performance in middle and late adulthood: The Human Connectome Project in Aging/Aging Adult Brain Connectome cohort.2027-01-01
PUBMEDGenetic risk for dystonia reprograms host-microbiome interactions and gut-brain communication.2027-01-01
PUBMEDPlasma inflammatory markers and brain white matter microstructure in late middle-aged and older adults.2027-01-01
PUBMEDNeuropathology of centenarians and supercentenarians: An autopsy study.2027-01-01
PUBMEDThe glioma metabolite, D-2-hydroxyglutarate (D-2-HG), reduces synaptic transmission and epileptiform bursts in neocortical slices.2027-01-01

World Bank context

IT.NET.USER.ZSinternet_users_pct94.7% · 2024
NY.GDP.MKTP.CDgdp_current_usd$30,769.7B · 2025
NY.GDP.PCAP.CDgdp_per_capita_usd$90,027 · 2025
SE.PRM.ENRRschool_enrollment_primary_pct96.97 · 2022
SE.SEC.ENRRschool_enrollment_secondary_pct97.47 · 2022
SH.XPD.CHEX.GD.ZScurrent_health_expenditure_pct_gdp16.7% · 2023
SH.XPD.CHEX.PC.CDcurrent_health_expenditure_per_capita_usd$13,473 · 2023
SH.XPD.GHED.GD.ZSgovernment_health_expenditure_pct_gdp9.0% · 2023
SP.DYN.CBRT.INbirth_rate_crude10.60 · 2024
SP.POP.TOTLpopulation_total341,784,857 · 2025
SP.URB.TOTL.IN.ZSurban_population_pct80.2% · 2025

Macro indicators are shown only where a timestamped World Bank source row exists. Latest collection in this report: 2026-10-24 04:18 UTC. They are context, not NeuroRisk predictions.

Sources and provenance

ClinicalTrials.gov provides NCT evidence. PubMed/NCBI and OpenAlex provide research metadata. OpenAlex links institutions. World Bank indicators are included only when an explicit source row and year exist. NeuroRisk transformations add normalization, ranking and graph connections.

Limitations

Indexed corpus counts are not guaranteed exhaustive global totals. Scores are comparative decision-support signals. This report is not medical advice, regulatory advice, patent clearance, an investment recommendation or a guarantee of outcome.